Mannobioside biomimetics that trigger DC-SIGN binding selectivity.

Irene Herrera-GonzálezMichel ThépautElena M Sánchez-FernándezAntonio Di MaioCorinne VivèsJavier Rojo José Manuel García Fernández Franck Fieschi Pedro M Nieto Carmen Ortiz Mellet

Published in: Chemical communications (Cambridge, England) (2022)

Selective DC-SIGN targeting vs . langerin might lead to anti-infective agents, given their counteracting effects upon infection by some pathogens. Here we show that multivalent sp 2 -iminosugar-containing mannobioside analogs can achieve total DC-SIGN selectivity by levering the canonic binding mode towards high-mannose oligosaccharide ligands, behaving as factual biomimics.

Keyphrases

dendritic cells
dna binding
binding protein
drug delivery
molecular dynamics simulations