MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome.

Samar RezqAlexandra M HuffmanJelina BasnetAmira E AlsemehJussara M do CarmoLicy L Yanes CardozoDamian G Romero

Published in: Biology of sex differences (2024)

Our findings suggest that BAT miR-21 may play a role in regulating DHT-mediated thermogenic dysfunction in PCOS. Modulation of BAT miR-21 levels could be a novel therapeutic approach for the treatment of PCOS-associated metabolic derangements.

Keyphrases

polycystic ovary syndrome
adipose tissue
insulin resistance
cell proliferation
long non coding rna
mouse model
long noncoding rna
high fat diet
high fat diet induced
metabolic syndrome
skeletal muscle
oxidative stress
combination therapy
smoking cessation