Biomimetic Approach toward Kinetically Stable AIE-Gens under Physiological Conditions.

Many AIE-gens suffer from excessive hydrophobicity, and their kinetic stability in aqueous condition is not warranted. Here, we introduce phosphorylcholine, a zwitterionic group ubiquitously found in biological membranes, onto the tetraphenylethene core structure to yield AIE nanoparticles stable in both PBS buffer and cell culture. We also find that the AIE efficiency is critically reliant on the delicate balance between the hydrophilic phosphorylcholine and hydrophobic moieties.