Prevalence and clinical characteristics of refractoriness to optimal proton pump inhibitor therapy in non-erosive reflux disease.

Mentore RibolsiMichele CicalaPatrizia ZentilinMatteo NeriAurelio MauroKonstantinos EfthymakisTommasangelo PetittiVincenzo SavarinoRoberto Penagini

Published in: Alimentary pharmacology & therapeutics (2018)

True refractoriness in patients with GERD symptoms attending a secondary care setting is lower than previously reported. Following a careful history and optimal PPI dosing, the rate of refractoriness was 20%. True NERD constitutes only a third of the PPI-refractory group.

Keyphrases

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risk factors
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sleep quality
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