Prevalence of BRCA1 and BRCA2 germline variants in an unselected pancreatic cancer patient cohort in Pakistan.

Noor MuhammadAyesha AzeemShumaila ArifHumaira NaeemiIqra MasoodUsman HassanBushra IjazFaisal HanifAamir Ali SyedMuhammed Aasim YusufMuhammad Usman Rashid

Published in: Hereditary cancer in clinical practice (2023)

In this first study, BRCA1/2 pathogenic variant is identified with a low frequency in pancreatic cancer patients from Pakistan. Comprehensive multigene panel testing is recommended in the Pakistani pancreatic cancer patients to enhance genetic understanding in this population.

Keyphrases

breast cancer risk
copy number
tertiary care
risk factors
case report
genome wide
dna repair
dna methylation
gene expression
oxidative stress