Partial oral versus full intravenous antibiotic treatment of endocarditis in people who inject drugs: A systematic review.
Amy BrownHallie L JeffersonPeter DaleyWilliam Dt KentDuncan WebsterCorey AdamsPublished in: Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada (2024)
There is limited evidence comparing IV treatment to partial IV, partial PO antibiotic treatment in PWID with IE. Observational studies suggest that PO antibiotic therapy after initial IV treatment may be equivalent to full IV treatment alone within specific parameters, but randomized trials are needed to inform recommendations. Substantial clinical and social benefits for PWID and advantages for the health care system will result if PO treatment strategies with equal efficacy can be implemented.