Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice.

Anh T P NgoKelley R JordanPaul A MuellerMatthew W HagenStéphanie E ReitsmaCristina PuyAlexey S RevenkoChristina U LorentzErik I TuckerQuifang ChengMonica T HindsSergio FazioBrett P MoniaDavid GailaniAndrás GruberHagai TavoriOwen J T McCarty

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Pharmacological targeting of FXI reduced atherogenesis in Ldlr-/- mice. Interference with the contact activation system may safely reduce development or progression of atherosclerosis.

Keyphrases

low density lipoprotein
cardiovascular disease
cancer therapy
type diabetes
high fat diet induced
radiation induced
binding protein