Biomimetic radiosensitizers unlock radiogenetics for local interstitial radiotherapy to activate systematic immune responses and resist tumor metastasis.

Jiajia ZhangMengdie YangXin FanMengqin ZhuYuzhen YinHongyan LiJie ChenShanshan QinHan ZhangKun ZhangFei Yu

Published in: Journal of nanobiotechnology (2022)

IRT radiosensitizer-unlocked radiogenetics and the corresponding design principle provide a general pathway to address the insufficient systematic immune responses of local IRT.

Keyphrases

immune response
early stage
dendritic cells
toll like receptor
radiation therapy
radiation induced
squamous cell carcinoma
inflammatory response
tissue engineering