Statistical considerations of nonrandom treatment applications reveal region-wide benefits of widespread post-fire restoration action.

Accurate predictions of ecological restoration outcomes are needed across the increasingly large landscapes requiring treatment following disturbances. However, observational studies often fail to account for nonrandom treatment application, which can result in invalid inference. Examining a spatiotemporally extensive management treatment involving post-fire seeding of declining sagebrush shrubs across semiarid areas of the western USA over two decades, we quantify drivers and consequences of selection biases in restoration using remotely sensed data. From following more than 1,500 wildfires, we find treatments were disproportionately applied in more stressful, degraded ecological conditions. Failure to incorporate unmeasured drivers of treatment allocation led to the conclusion that costly, widespread seedings were unsuccessful; however, after considering sources of bias, restoration positively affected sagebrush recovery. Treatment effects varied with climate, indicating prioritization criteria for interventions. Our findings revise the perspective that post-fire sagebrush seedings have been broadly unsuccessful and demonstrate how selection biases can pose substantive inferential hazards in observational studies of restoration efficacy and the development of restoration theory.