Whole genome sequencing identifies etiology of recurrent male intrauterine fetal death.

Omar ShehabDavid J TesterNicholas C AckermanF Susan CowchockMichael J Ackerman

Published in: Prenatal diagnosis (2017)

Here, we demonstrate the utility of whole genome sequencing-based pedigree analysis to identify the genetic cause for recurrent IUFD when chromosome studies, including microarray analysis, are normal. Further studies are needed to determine the prevalence of FOXP3-mediated IUFD in males. © 2017 John Wiley & Sons, Ltd.

Keyphrases

genome wide
regulatory t cells
risk factors
copy number
immune response
case control