The Simultaneous Effects of miR-145-5p and hsa-let-7a-3p on Colorectal Tumorigenesis: In Vitro Evidence.

Nazila MozammelElham BaghbaniMohammad AminiSheyda Jodeiry ZaerYalda Baghay EsfandyariMaryam TohidastSeyed Samad HosseiniSeyed Ali RahmaniAmir Ali Mokhtarzadeh Behzad Baradaran

Published in: Advanced pharmaceutical bulletin (2023)

Taken together, considering that exogenous overexpression of MIR-145 and hsa-let-7a showed cooperative anti-cancer effects on CRC cells, their combination may be considered as a novel therapeutic strategy for the treatment of CRC.

Keyphrases

cell proliferation
induced apoptosis
long non coding rna
cell cycle arrest
long noncoding rna
transcription factor
endoplasmic reticulum stress
oxidative stress
cell death