Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS.

Liping YuXiaorong ZhangTianqi WuJin SuYuyang WangYuexin WangBaoyang RuanXiaosai NiuYantao Wu

Published in: BMC veterinary research (2017)

Although chicken MDA5 (chMDA5) is functionally active during IBV infection, the absence of RIG-I may increase the susceptibility of chickens to IBV infection, and IBV may disrupt the activation of the host antiviral response through the cleavage of MAVS.

Keyphrases

signaling pathway
breast cancer cells
dna binding
epithelial mesenchymal transition
copy number
cell cycle arrest
heat stress
cell proliferation
transcription factor
induced apoptosis
amino acid
endoplasmic reticulum stress