Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.

Yufeng DaiRuijie XuJinxiang ChenJialong FangHao ZhangHaitao LiWei Chen

Published in: British journal of pharmacology (2023)

/CaMKIIγ to activate PERK-Chop-TRB3 signalling. Inhibition of hepatocyte TP receptors improved hepatic steatosis and inflammation. The TP receptor is a new therapeutic target for NAFLD and metabolic syndrome.

Keyphrases

endoplasmic reticulum stress
insulin resistance
metabolic syndrome
induced apoptosis
high fat diet
adipose tissue
skeletal muscle
high fat diet induced
oxidative stress
polycystic ovary syndrome
type diabetes
diffuse large b cell lymphoma
uric acid
liver fibrosis
cardiovascular risk factors
signaling pathway