Hereditary breast cancer next-generation sequencing (NGS) panel evaluation in the south region of Brazil: a novel BRCA2 candidate pathogenic variant is reported.
Cesar Augusto B DuarteCarlos Alberto Dos SantosCristine Domingues D de OliveiraCleverton César SpautzLaura Masami SumitaSueli Massumi NakataniPublished in: medRxiv : the preprint server for health sciences (2024)
In this article, we delineate a loosely selected cohort comprising patients with a history of early-onset breast cancer and/or a familial occurrence of cancer. The aim of this study was to gain insights into the presence of breast cancer-related gene variants in a population from a micro-region in southern Brazil, specifically the Metropolitan Region of Curitiba. This area exhibits a highly genetically mixed population, mirroring the general characteristics of the Brazilian people. Comprehensive next-generation sequencing (NGS) multigene panel testing was conducted, involving the evaluation of twelve patients. Two pathogenic variants and one candidate pathogenic variant were identified: BRCA2 :c.8878C>T, p.Gln2960Ter; CHEK2 :c.1100delAG>A, p.Thr367Metfs*15 and BRCA2 :c.3482dupG>GA, p.Asp1161Glufs*3, a novel variant, previously unpublished, is reported.
Keyphrases
- early onset
- copy number
- breast cancer risk
- late onset
- end stage renal disease
- ejection fraction
- newly diagnosed
- genome wide
- papillary thyroid
- risk assessment
- prognostic factors
- peritoneal dialysis
- patient reported outcomes
- circulating tumor
- squamous cell carcinoma
- young adults
- gene expression
- squamous cell
- circulating tumor cells