Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats.

Meihua LiCan ZhengToru KawadaMasashi InagakiKazunori UemuraTsuyoshi AkiyamaMasaru Sugimachi

Published in: Cardiovascular drugs and therapy (2020)

Peripheral blockade of α7-nAChR significantly attenuated the cardioprotective effects of donepezil in CHF rats, whereas central blockade did not. This suggests that peripheral activation of α7-nAChR plays an important role in cholinergic pharmacotherapy for CHF.

Keyphrases

chemotherapy induced
smoking cessation