Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression.

Anna Besschetnova Wanting Han Mingyu Liu Yanfei Gao Muqing Li Zifeng Wang Maryam Labaf Susan Patalano Kavita Venkataramani Rachel E Muriph Jill A Macoska Kellee Renee Siegfried Jason J Evans Steven P Balk Shuai Gao Dong Han Changmeng Cai

Published in: Cancer research communications (2023)

In this study, we demonstrate that EHMT1 and EHMT2 proteins drive prostate cancer development by transcriptionally activating multiple oncogenic pathways. Mechanistically, the chromatin binding of EHMT1 is significantly expanded through demethylation of both lysine 450 and 451 residues, which can serve as a critical molecular switch to induce oncogenic transcriptional reprogramming in prostate cancer cells.

Keyphrases

prostate cancer
transcription factor
radical prostatectomy
gene expression
dna binding
dna damage
signaling pathway
binding protein
amino acid
heat shock
oxidative stress
protein protein
small molecule
heat shock protein