Noroviruses: Evolutionary Dynamics, Epidemiology, Pathogenesis, and Vaccine Advances-A Comprehensive Review.
Cornelius Arome OmatolaPhilip Paul MshelbwalaMartin-Luther Oseni OkoloAnyebe Bernard OnojaJoseph Oyiguh AbrahamDavid Moses AdajiSunday Ocholi SamsonTherisa Ojomideju OkemeRuth Foluke AminuMonday Eneojo AkorGideon AyeniDanjuma MuhammedPhoebe Queen AkohDanjuma Salisu IbrahimEmmanuel EdegboLamidi YusufHelen Ojomachenwu OceanSumaila Ndah AkpalaOiza Aishat MusaAndrew Musa AdamuPublished in: Vaccines (2024)
Noroviruses constitute a significant aetiology of sporadic and epidemic gastroenteritis in human hosts worldwide, especially among young children, the elderly, and immunocompromised patients. The low infectious dose of the virus, protracted shedding in faeces, and the ability to persist in the environment promote viral transmission in different socioeconomic settings. Considering the substantial disease burden across healthcare and community settings and the difficulty in controlling the disease, we review aspects related to current knowledge about norovirus biology, mechanisms driving the evolutionary trends, epidemiology and molecular diversity, pathogenic mechanism, and immunity to viral infection. Additionally, we discuss the reservoir hosts, intra-inter host dynamics, and potential eco-evolutionary significance. Finally, we review norovirus vaccines in the development pipeline and further discuss the various host and pathogen factors that may complicate vaccine development.
Keyphrases
- healthcare
- end stage renal disease
- genome wide
- risk factors
- endothelial cells
- chronic kidney disease
- newly diagnosed
- sars cov
- peritoneal dialysis
- prognostic factors
- late onset
- intensive care unit
- induced pluripotent stem cells
- middle aged
- patient reported outcomes
- single molecule
- respiratory failure
- social media
- community dwelling
- climate change
- amyotrophic lateral sclerosis