Surface Plasmon Resonance based-optical biosensor: Emerging diagnostic tool for early detection of diseases.

The development of diagnostic tools remains at the centre of the health care system. In recent times optical biosensors have been widely applied in the scientific community, especially for monitoring protein-protein or nucleic acid hybridization interactions. Optical biosensors derived Surface Plasmon Resonance (SPR) technology has appeared as a revolutionary technology at the current times. This review focuses on the research work in molecular biomarker evaluation using the technique based on SPR for translational clinical diagnosis. The review has covered both communicable and non-communicable diseases by using different bio-fluids of the patient's sample for diagnosis of the diseases. An increasing number of SPR approaches have been developed in health care research and fundamental biological studies. The utility of SPR in the area of biosensing basically lies in its non-invasive diagnostic and prognostic feature due to its label free, high sensitivity and specificity properties. This makes SPR an invaluable tool with precise application in the recognition of different stages of the disease. This article is protected by copyright. All rights reserved.