Derivation and Validation of Thresholds Using Synthetic Data Methods for Single-Test Screening of Emergency Department Patients with Possible Acute Myocardial Infarction Using a Point-of-Care Troponin Assay.
John William PickeringJoanna M YoungPeter M GeorgeAntony S WatsonSally J AldousToby VerrytRichard W TroughtonChristopher J PembertonArthur Mark RichardsLouise Ann CullenFred S AppleMartin P ThanPublished in: The journal of applied laboratory medicine (2024)
With the TnI-Nx assay, we successfully demonstrated an approach using synthetic data generation to derive low-risk thresholds for safe and effective screening.