Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients.
Gabriel HundeshagenDavid N HerndonKarel D CapekLudwik K BranskiCharles D VoigtElizabeth A KillionJanos Cambiaso-DanielMichaela SljivichAndrew De CrescenzoRonald P MlcakMichael P KinskyCeleste C FinnertyWilliam B NorburyPublished in: Critical care (London, England) (2017)
Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in pediatric and adult burn patients when compared to vancomycin alone or vancomycin plus imipenem-cilastin. The mechanism of this increased nephrotoxicity remains elusive and warrants further scientific evaluation.