Anti-epileptic drug use and subsequent degenerative dementia occurrence.
Naoki IkegayaHonoka NakamuraYutaro TakayamaYohei MiyakeTakahiro HayashiMasaki SonodaMitsuru SatoKensuke TateishiJun SuenagaMasao TakaishiYu KitazawaMisako KuniiHiroki AbeTomoyuki MiyazakiTetsuaki AraiManabu IwasakiTakayuki AbeTetsuya YamamotoPublished in: Alzheimer's & dementia (New York, N. Y.) (2024)
Anti-epileptic drug (AED) use before epilepsy diagnosis was linked with a lower subsequent degenerative dementia (DD) occurrence.Identifying the epileptic phenotype was crucial for justifying early AED use in DD.AED use with an epilepsy diagnosis did not pose an additional risk of DD.The potential contribution of combination drug therapy to the strategy was noted.