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Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring.

Sharon DavideskoKira Nahum SacksMichael FrigerAlon HaimEyal Sheiner
Published in: Hypertension in pregnancy (2020)
Objective: To analyze preeclampsia as a risk factor for pediatric endocrine disease. Study Design: A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia. Results: The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; p < 0.001), specifically obesity (0.4% vs 0.2%, p < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115-1.841 p = 0.005). Conclusion: Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.
Keyphrases
  • early onset
  • high fat diet
  • insulin resistance
  • metabolic syndrome
  • type diabetes
  • weight loss
  • pregnant women
  • young adults
  • weight gain
  • adipose tissue
  • high fat diet induced
  • preterm infants
  • gestational age