Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia.

Dongyuan Zhang Yu ZhangJirong PanJingjing CaoXiuping SunXianglei LiLing ZhangChuan Qin

Published in: CNS neuroscience & therapeutics (2023)

P62 recognizes and binds to ubiquitin-modified NLRP3. It plays a vital role in regulating the inflammatory response by participating in ALP-associated NLRP3 protein degradation, which improves cognitive function in AD by reducing the pro-inflammatory status and pyroptosis of microglia, thus maintaining its phagocytic function.

Keyphrases

inflammatory response
nlrp inflammasome
lipopolysaccharide induced
lps induced
toll like receptor
neuropathic pain
cell death
signaling pathway
oxidative stress
immune response
protein protein