Immunoinformatic approach to assess SARS-CoV-2 protein S epitopes recognised by the most frequent MHC-I alleles in the Brazilian population.

Ronald Rodrigues de MouraAlmerinda AgrelliCarlos André Santos-SilvaNatália SilvaBruno Rodrigo AssunçãoLucas BrandãoAna Maria Benko-IsepponSergio Crovella

Published in: Journal of clinical pathology (2020)

Being aware of the intrinsic limitations of in silico analysis (mainly the differences between the real and the Protein Data Bank (PDB) structure; and accuracy of the methods for simulate proteasome cleavage), we identified 24 epitopes able to interact with 17 MHC-I more frequent alleles in the Brazilian population that could be useful for the development of strategic methods for vaccines against SARS-CoV-2.

Keyphrases

sars cov
respiratory syndrome coronavirus
protein protein
electronic health record
molecular docking
machine learning
dna binding
transcription factor