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Genetic association tests in family samples for multi-category phenotypes.

Shuai WangJames B MeigsJosée Dupuis
Published in: BMC genomics (2021)
Both proposed tests have correct type-I error rate and similar power. However, because the Wald statistics rely on computer-intensive estimation, it is less efficient than the score test in terms of applications to large-scale genetic association studies. We provide computer implementation for both multinomial and ordinal traits.
Keyphrases
  • genome wide
  • deep learning
  • primary care
  • healthcare
  • copy number
  • dna methylation
  • quality improvement