Dynamic Kinetic Resolution of Aldehydes by Hydroacylation.

Zhiwei ChenYusuke AotaHillary M H NguyenVy M Dong

Published in: Angewandte Chemie (International ed. in English) (2019)

We report a dynamic kinetic resolution (DKR) of chiral 4-pentenals by olefin hydroacylation. A primary amine racemizes the aldehyde substrate via enamine formation and hydrolysis. Then, a cationic rhodium catalyst promotes hydroacylation to generate α,γ-disubstituted cyclopentanones with high enantio- and diastereoselectivities.

Keyphrases

ionic liquid
single molecule
reduced graphene oxide
highly efficient
capillary electrophoresis
carbon dioxide
metal organic framework
amino acid
structural basis