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Specific Features of Juvenile Idiopathic Arthritis Patients' Chemokine Profile: The Data of Case-Control Study Analysis.

Arseniy V RybakovKarina A YurevaVitaliy V KhizhaDaria I KozlovaLybov S SorokinaVyacheslav I ZorinAleksei N KozhevnikovMikhail M Kostik
Published in: Current rheumatology reviews (2024)
An increase in their content leads to active monocytes/macrophages migration to the site of inflammation, where they suppress effector T-cell activity by binding suppressor exosomes and activate B-cells by autoantigens presentation received due to joint tissue destruction. This allows us to speak about the predominance of the Th1-mediated immune response during the development of studied disease chronic inflammation.
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