Specific Features of Juvenile Idiopathic Arthritis Patients' Chemokine Profile: The Data of Case-Control Study Analysis.
Arseniy V RybakovKarina A YurevaVitaliy V KhizhaDaria I KozlovaLybov S SorokinaVyacheslav I ZorinAleksei N KozhevnikovMikhail M KostikPublished in: Current rheumatology reviews (2024)
An increase in their content leads to active monocytes/macrophages migration to the site of inflammation, where they suppress effector T-cell activity by binding suppressor exosomes and activate B-cells by autoantigens presentation received due to joint tissue destruction. This allows us to speak about the predominance of the Th1-mediated immune response during the development of studied disease chronic inflammation.
Keyphrases
- juvenile idiopathic arthritis
- immune response
- end stage renal disease
- oxidative stress
- dendritic cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- stem cells
- mesenchymal stem cells
- peritoneal dialysis
- rheumatoid arthritis
- peripheral blood
- big data
- disease activity
- patient reported outcomes
- case report
- bone marrow
- systemic lupus erythematosus
- inflammatory response
- data analysis
- binding protein
- solid state