Hemimycale Arabica Induced Non-Cytotoxic Anti-Migratory Activity in Hepatocellular Carcinoma In Vitro.
Hanaa Mahrous RadyAmal Z HassanHowaida I Abd-AllaHaiam Abdel RaoufSohair M SalemPublished in: Asian Pacific journal of cancer prevention : APJCP (2022)
Total ethanol extract is a promising non-cytotoxic anticancer agent because of its powerful apoptosis induction and capability to block tumor cell migration. Petroleum ether and ether fractions area weak non-cytotoxic anti-migratory agents. Dichloromethane could be a moderate cytotoxic anti-migratory agent induced caspase-independent apoptosis. It could be used in anticancer therapy for VEGF-resistance patients through downregulation of FGF. Ethyl acetate fraction considered a non-cytotoxic agent exerting moderate anti-migratory activity. The new sponge-derived treatments can solve different resistance problems to find a convenient treatment for each individual case using a single agent.
Keyphrases
- oxidative stress
- cell migration
- cell death
- diabetic rats
- high glucose
- endoplasmic reticulum stress
- end stage renal disease
- mental health
- newly diagnosed
- endothelial cells
- chronic kidney disease
- ionic liquid
- cell cycle arrest
- cell proliferation
- signaling pathway
- prognostic factors
- induced apoptosis
- drug induced
- anti inflammatory
- stress induced