Dysfunction of proprioceptive sensory synapses is a pathogenic event and therapeutic target in mice and humans with spinal muscular atrophy.

C M SimonN DelestreeJ MontesF GerstnerE CarranzaL SowoidnichJ M BuettnerJ G PagiazitisG Prat-OrtegaS EnselS DonadioJ L GarciaP KratimenosW K ChungC J SumnerL H WeimerE PirondiniMarco CapogrossoL PellizzoniDc De VivoGeorge Z Mentis

Published in: medRxiv : the preprint server for health sciences (2024)

Sensory-motor circuit dysfunction involving impairment of proprioceptive synapses on motor neurons is a conserved pathogenic event and therapeutic target across animal models and humans with spinal muscular atrophy.

Keyphrases

oxidative stress
spinal cord
transcription factor
high fat diet induced
type diabetes
metabolic syndrome
insulin resistance