Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer.

Simona PellecchiaMelania FranchiniGaetano ViscidoRiccardo ArneseGennaro Gambardella

Published in: Genome medicine (2024)

Our strategy proved effective in reconstructing the complex signalling network driving EGFR-targeted therapy resistance, offering new insights for the development of individualized treatment strategies in TNBC.

Keyphrases

single cell
small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
rna seq
bone marrow
cell fate