Multicenter Evaluation of Independent High-Throughput and RT-qPCR Technologies for the Development of Analytical Workflows for Circulating miRNA Analysis.

Anna BabayanMartin H D NeumannAndrei HerdeanJonathan M ShafferMelanie JanningFranca KobusSonja LogesFrancesca Di PasqualeMikael KubistaMartin SchlumpbergerRita LampignanoThomas KrahnThomas SchlangeMarkus Sprenger-HausselsKlaus PantelVera Kloten

Published in: Cancers (2020)

Changing of (pre)-analytical methods of miRNA analysis has a significant impact on blood test results and is therefore a major confounding factor. In addition, to confirm miRNA biomarker candidates screening studies should be followed by targeted validation using an independent platform or technology.

Keyphrases

high throughput
clinical trial
single cell
cancer therapy
drug delivery