Sex discrepancy in the reduction of mucosal-associated invariant T cells caused by obesity.

Jianyun LiuHongmei NanRandy R BrutkiewiczJose CasasnovasKok Lim Kua

Published in: Immunity, inflammation and disease (2020)

Our study suggests that there is a sex discrepancy in the impact of obesity on MAIT cells: MAIT cells in male (but not female) humans and male mice are reduced by obesity.

Keyphrases

induced apoptosis
insulin resistance
metabolic syndrome
weight loss
type diabetes
cell cycle arrest
high fat diet induced
weight gain
endoplasmic reticulum stress
oxidative stress
skeletal muscle
physical activity
cell death
signaling pathway
adipose tissue
cell proliferation
body mass index