High Fat High Sugar Diet Reduces Small Intestinal Secretion by Sex-Dependent Mechanisms.

Kyle MillerSarah CarpinelliMaxwell RubinJohn AhlertAaron KubinskiBrendan Van ItenKendra SyBryan LuntKaterina MeassickStephen AmesEmma SmithChaheyla R St AubinLayla Al-Nakkash

Published in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (2023)

in HFS mice is attributed to sex-dependent mechanisms and while exercise partially mitigated this, it's mechanism of action was unclear. Improved understanding of Western diet induced intestinal dysfunctions may allow for the development of novel drug targets to treat gastrointestinal disturbances in diabetic obesity.

Keyphrases

high fat diet induced
weight loss
type diabetes
physical activity
insulin resistance
metabolic syndrome
high intensity
south africa
weight gain
wound healing
resistance training
emergency department
skeletal muscle
body composition
adverse drug