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Paediatric patients with Cushing disease and negative pituitary MRI have a higher risk of nonremission after transsphenoidal surgery.

Christina TatsiMaria E BompouChelsi FlippoMargaret F KeilPrashant ChittiboinaConstantine A Stratakis
Published in: Clinical endocrinology (2021)
Up to one-third of paediatric and adolescent patients with CD do not have a pituitary tumour visualised in MRI. A negative MRI is associated with higher odds of nonremission after surgery; however, if remission is achieved, long-term risk for recurrence is not associated with the preoperative MRI findings.
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