Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs.

Bodo HaasVeronika KlingerChristina KekselVerena BonigutDaniela KieferJulia CaspersJulia WaltherMaria Wos-MagangaSandra WeickhardtGabriele RöhnMarco TimmerRoland FrötschlNiels Eckstein

Published in: Cancer cell international (2018)

Temozolomide treatment naive and TMZ resistant GBM biopsies show a distinct activation pattern of the MEK/ERK and PI3K signaling cascades indicating a role of these pathways in resistance development. Both pathways are also activated in GBM cell lines, however, only the PI3K pathway seems to play a crucial role in resistance to alkylating agents and might serve as drug target for chemosensitization.

Keyphrases

pi k akt
signaling pathway
cell proliferation
endothelial cells
induced apoptosis
hiv infected
induced pluripotent stem cells
drug induced
newly diagnosed