Harnessing natural killer cell effector function against cancer.
Matthew D BluntSalim I KhakooPublished in: Immunotherapy advances (2023)
Natural killer (NK) cells are cytotoxic innate lymphoid cells that participate in anti-tumour and anti-viral immune responses. Their ability to rapidly destroy abnormal cells and to enhance the anti-cancer function of dendritic cells, CD8+ T cells, and macrophages makes them an attractive target for immunotherapeutic strategies. The development of approaches that augment NK-cell activation against cancer is currently under intense preclinical and clinical research and strategies include chimeric antigen receptor NK cells, NK-cell engagers, cytokines, and immune checkpoint inhibitors. In this review, we highlight recent advances in NK-cell therapeutic development and discuss their potential to add to our armamentarium against cancer.
Keyphrases
- nk cells
- dendritic cells
- papillary thyroid
- immune response
- induced apoptosis
- squamous cell
- cell cycle arrest
- regulatory t cells
- sars cov
- single cell
- squamous cell carcinoma
- endoplasmic reticulum stress
- cell proliferation
- inflammatory response
- toll like receptor
- big data
- bone marrow
- deep learning
- artificial intelligence