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Imputation strategies for genomic prediction using nanopore sequencing.

Harrison J LambL T NguyenJ P CopleyB N EngleB J HayesE M Ross
Published in: BMC biology (2023)
Here we demonstrated accurate genomic prediction is possible with ONT sequence data from sequencing coverages as low as 0.1 × , and imputation time can be as short as 10 min per sample. We also demonstrate that in this population, genotyping-by-sequencing at 0.1 × coverage can be more accurate than imputation from low-density SNP arrays.
Keyphrases
  • single cell
  • genome wide
  • copy number
  • high resolution
  • high throughput
  • electronic health record
  • single molecule
  • healthcare
  • big data
  • gene expression
  • machine learning
  • mass spectrometry
  • artificial intelligence