Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer.
Jonghoon KimHye Rim ChoHyejin JeonDokyoon KimChangyeong SongNohyun LeeSeung Hong ChoiTaeghwan HyeonPublished in: Journal of the American Chemical Society (2017)
Therapeutic effects of photodynamic therapy (PDT) are limited by cancer hypoxia because the PDT process is dependent on O2 concentration. Herein, we design biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nanoparticles (MFMSNs) to overcome hypoxia, consequently enhancing the therapeutic efficiency of PDT. By exploiting the continuous O2-evolving property of MnFe2O4 nanoparticles through the Fenton reaction, MFMSNs relieve hypoxic condition using a small amount of nanoparticles and improve therapeutic outcomes of PDT for tumors in vivo. In addition, MFMSNs exhibit T2 contrast effect in magnetic resonance imaging (MRI), allowing in vivo tracking of MFMSNs. These findings demonstrate great potential of MFMSNs for theranostic agents in cancer therapy.
Keyphrases
- photodynamic therapy
- magnetic resonance imaging
- fluorescence imaging
- papillary thyroid
- cancer therapy
- contrast enhanced
- squamous cell
- magnetic resonance
- endothelial cells
- drug delivery
- walled carbon nanotubes
- type diabetes
- squamous cell carcinoma
- hydrogen peroxide
- wastewater treatment
- lymph node metastasis
- iron oxide
- climate change
- young adults