Increased activity of MAPKAPK2 within mesenchymal cells as a target for inflammation associated fibrosis in Crohn's Disease.

Marina ChulkinaChristina RohmerSteven McAninchRonaldo Paolo PanganibanRomain VillégerAustin PortoleseJustin CiocirlanWenjing YangClaire CohenWalter KoltunJohn F ValentineYingzi CongGregory YochumEllen J BeswickIrina V Pinchuk

Published in: Journal of Crohn's & colitis (2024)

Our data suggest that activation of MK2 within fibroblasts contributes to the chronic inflammation induced fibrosis in CD and that targeting MK2 has potential for the development of novel therapeutic approaches for fibrosis in CD.

Keyphrases

oxidative stress
induced apoptosis
diabetic rats
stem cells
bone marrow
cell cycle arrest
electronic health record
nk cells
risk assessment
big data
human health
endoplasmic reticulum stress
endothelial cells
cell death
extracellular matrix