The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and App NL-F/NL-F mice.
Cristina Nuñez-DiazEmelie AnderssonNina SchultzDovilė PocevičiūtėOskar Hanssonnull nullK Peter R NilssonMalin WennströmPublished in: Alzheimer's research & therapy (2024)
Our study suggests that the microglial capability to uptake p-tau in the retina persists and intensifies with AD progression. These results also highlight bTVBT2 as a ligand of interest in future monitoring of retinal AD pathology.
Keyphrases
- diabetic retinopathy
- end stage renal disease
- optical coherence tomography
- optic nerve
- ejection fraction
- inflammatory response
- newly diagnosed
- chronic kidney disease
- neuropathic pain
- cerebrospinal fluid
- peritoneal dialysis
- prognostic factors
- type diabetes
- adipose tissue
- living cells
- current status
- spinal cord injury
- high fat diet induced
- fluorescent probe