HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.
Maolian GongYong YuLei LiangDogus VuralliSebastian FroehlerPeter KuehnenPhilipp Du BoisJingjing ZhangAidi CaoYuantao LiuKhalid HussainJens FielitzShiqi JiaWei ChenKlemens RailePublished in: Molecular genetics & genomic medicine (2019)
Mutations in HDAC4 disrupt the deacetylation of FoxO1, subsequently decrease the β-cell function including insulin secretion, resulting in diabetes.