The Essential Role of O-GlcNAcylation in Hepatic Differentiation.

Dakota R RobartsManasi KotulkarDiego Paine-CabreraKaitlyn K VennemanJohn A Hanover Natasha E Zachara Chad Slawson Udayan Apte

Published in: bioRxiv : the preprint server for biology (2023)

Single-Cell RNA-sequencing reveals loss of metabolic liver zonation in O-GlcNAcylation deficient livers.Loss of O-GlcNAcylation promoted DEN-Induced HCC.Increase of hepatic O-GlcNAcylation prevented HCC progression.

Keyphrases

single cell
rna seq
high throughput
high glucose
diabetic rats
drug induced
endothelial cells