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DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients.

Maria Belland OlsenCamilla HuseMirta Mittelstedt Leal de SousaSarah Louise MurphyAntonio SarnoTobias Sebastian ObermannKuan YangJan Cato HolterMarte Jøntvedt JørgensenErik Egeland ChristensenWei WangPing JiLars HeggelundHedda HoelAnne Margarita Dyrhol-RiiseIda GregersenPål AukrustMagnar BjøråsBente HalvorsenTuva Børresdatter Dahl
Published in: Journal of inflammation research (2022)
Although beneficial by protecting against DNA damage, long-term activation of the DNA repair machinery could also contribute to persistent inflammation, potentially through mechanisms such as the induction of cellular senescence. However, further studies that also include measurements of additional markers of DNA damage are required to determine the role and precise molecular mechanisms for DNA repair in SARS-CoV-2 infection.
Keyphrases
  • dna repair
  • dna damage
  • oxidative stress
  • dna damage response
  • sars cov
  • coronavirus disease