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Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing.

Ester Del DucaJuan RuanoA B PavelR D SanyalT SongJesús Gay-MimbreraN ZhangYeriel D EstradaX PengYael Renert-YuvalR G PhelpsRalf PausJames G KruegerEmma Guttman-Yassky
Published in: The British journal of dermatology (2020)
These data suggest that follicular damage and loss of stem cells in FFA may be mediated through immune attack in the bulge region, with secondary fibrosis and reduced but still detectable stem cells. JAK/STAT-targeting treatments may be able to prevent permanent follicular destruction and fibrosis in early disease stages.
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