The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.
Kyle MaloneAndrea C Diaz DiazJennifer A ShearerAnne C MooreChristian WaeberPublished in: Journal of neuroinflammation (2021)
Fingolimod increases Treg frequency in spleen and blood post-ischaemia and enhances the number of FoxP3+ cells in the ischaemic brain. The effect of fingolimod on this regulatory cell population may underlie its neuroprotective activity and could be exploited as part of future stroke therapy.
Keyphrases
- regulatory t cells
- multiple sclerosis
- white matter
- cerebral ischemia
- mouse model
- dendritic cells
- resting state
- induced apoptosis
- functional connectivity
- cell cycle arrest
- single cell
- subarachnoid hemorrhage
- cell therapy
- brain injury
- blood brain barrier
- stem cells
- oxidative stress
- signaling pathway
- cell proliferation
- pi k akt