Novel Deleterious nsSNPs within MEFV Gene that Could Be Used as Diagnostic Markers to Predict Hereditary Familial Mediterranean Fever: Using Bioinformatics Analysis.

Mujahed I Mustafa Tebyan A AbdelhameedFatima A AbdelrhmanSoada A OsmanMohamed A Hassan

Published in: Advances in bioinformatics (2019)

This is the first in silico analysis of MEFV gene to prioritize SNPs for further genetic mapping studies. After using multiple bioinformatics tools to compare and rely on the results predicted, we found 23 novel mutations that may cause FMF disease and it could be used as diagnostic markers for Mediterranean basin populations.

Keyphrases

genome wide
copy number
bioinformatics analysis
dna methylation
climate change
high resolution
molecular docking
early onset
gene expression
high density
mass spectrometry