Dual-targets fluorescent nanoprobe for precise subtyping of lung cancer.

Zixuan ChangMing JiaGao LiuHoubang YangYinian WangMingyi OuyangXiaonan Gao Bo Tang

Published in: Chemical communications (Cambridge, England) (2024)

A Au-Se bond-based nanoprobe using 3',3-diselenopropionic acid to simultaneously link response chains for Pro-GRP protein and Cyfra21-1 was developed. Early diagnosis and subtyping of lung cancer can be achieved based on the nanoprobes' differential response of the probes to the two targets in lung cancer patients' serum.

Keyphrases

living cells
fluorescent probe
fluorescence imaging
small molecule
quantum dots
endoplasmic reticulum stress
photodynamic therapy
cell surface
nucleic acid
visible light