Inhibition of EGFR Signaling and Activation of Mitochondrial Apoptosis Contribute to Tanshinone IIA-Mediated Tumor Suppression in Non-Small Cell Lung Cancer Cells.
Feng GaoMing LiWenbin LiuWei LiPublished in: OncoTargets and therapy (2020)
Our data indicate that Tan IIA acts as an EGFR signaling inhibitor, and targeting EGFR-Akt-Mcl1 axis could provide a new option for NSCLC treatment.
Keyphrases
- small cell lung cancer
- epidermal growth factor receptor
- tyrosine kinase
- oxidative stress
- advanced non small cell lung cancer
- brain metastases
- single cell
- signaling pathway
- cell proliferation
- cell therapy
- electronic health record
- cancer therapy
- cell cycle arrest
- machine learning
- drug delivery
- mesenchymal stem cells