Prostate cancer cells synergistically defend against CD8 + T cells by secreting exosomal PD-L1.

Dameng LiXueying ZhouWenxian XuYuxin ChenChenglong MuXinchun ZhaoTao YangGang WangLiang WeiBo Ma

Published in: Cancer medicine (2023)

In summary, tumor cells share PD-L1 synergistically against T cells through exosomes. Inhibition of exosome secretion or prevention of PD-L1 sorting into exosomes may improve the therapeutic response of prostate tumors to anti-PD-L1 therapy.

Keyphrases

mesenchymal stem cells
stem cells
prostate cancer
benign prostatic hyperplasia
cell therapy
bone marrow