Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells.

Stéphane DemineAndrea Alex SchiavoSandra Marín-CañasPiero MarchettiMiriam CnopDecio L Eizirik

Published in: Stem cell research & therapy (2020)

Our data show that human iPSC-derived beta cells respond to pro-inflammatory cytokines IL-1β + IFNγ and IFNα, by activating the same pathogenic processes as adult human primary beta cells. These cells thus represent a valuable tool for future research on the pathogenesis of type 1 diabetes.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
cell cycle arrest
cell death
endothelial cells
signaling pathway
induced pluripotent stem cells
oxidative stress
immune response
dendritic cells
machine learning
young adults
deep learning
big data